Ph.D. Yale University, Pharmacology
B.A. Mount Holyoke College, Biology
Signaling pathways in cancer
New therapeutic targets for rational drug design
Signaling by protein tyrosine phosphatases
Recently Published Articles
Tworkoski K, Zito CI, Singahl G, Szpakowski S, Muthusamy V, Bacchiocchi A, Bosenberg
M, Krauthammer M, Halaban R, Stern DF. (2011) Phospho-proteomic screen identifies
novel therapeutic targets in melanoma. Molecular Cancer Research 9: 801.
Toy EP, Azodi M, Folk NL, Ivins CM, Zeiss CJ, Chambers SK. (2009) Enhanced ovarian
cancer tumorigenesis and metastasis by the macrophage colony stimulating factor (CSF-1).
Neoplasia 11(2): 136-144.
Zito CI, Riches DR, Kolmakova J, Simons JF, Egholm M, Stern DR. (2008) Direct resequencing
of the complete ERBB2 coding sequence reveals an absence of activating mutations in
ERBB2 amplified breast cancer. Genes Chromosomes Cancer. 47 (7), 633-8.
Zito CI, Qin H, Blenis J, Bennett AM. (2007) SHP-2 regulates cell growth by controlling
the mTOR/S6 kinase 1 pathway. J. Biol. Chem. 282(10): 6946- 6953.
Uhlén P, Burch PM, Zito CI, Estrada M, Ehrlich BE, Bennett AM. (2006) Gain-of-function/Noonan
syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling.
Proc. Natl. Acad. Sci. USA 103(7): 2160-2165.
Kolli S, Zito CI, Mossink MH, Wiemer EAC, Bennett AM. (2004). The major vault protein
is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal
growth factor signaling. J Biol Chem 279(28):29374-85.
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Chambers SK, Ivins CM, Kacinski BM, Hochberg RB. (2004) An unexpected effect of glucocorticoids
on stimulation of c-fms proto-oncogene expression in choriocarcinoma cells that express
little glucocorticoid receptor. Am J Obstet Gynecol. 190(4):974-85.
Kontaridis MI, Eminaga SE, Fornaro M, Zito CI, Sordella R, Settleman J, Bennett AM.
(2004). SHP-2 positively regulates myogenesis by coupling to the Rho GTPase Signaling
Pathway. Mol Cell Biol 24(12):5340-52.
Ivins Zito C, Kontaridis MI, Fornaro M, Feng G, Bennett AM. (2004). SHP-2 regulates
the phosphatidylinositide 3’-kinase/ akt pathway and suppresses caspase-3 mediated
apoptosis. J Cell Physiol. 199(2):227-36.
The Cellular and Molecular Biology program was licensed by the State of Connecticut
Department of Higher Education in January of 1995. We have about 30 full-time students
and 15 part-time students enrolled in the program with about 40% being international
students from a variety of countries. People employed in the New Haven area's biotechnical
and pharmaceutical industries make up most of our part-time enrollment. The students
attending part-time take advantage of the "evening only" class schedule which allows
them to continue their full-time employment in the field. The entire graduate program
at the University of New Haven is on an accelerated schedule with three full trimesters
a year. This allows full-time students to complete the Cellular and Molecular Biology
program in about 16 months and part-time students to complete the degree in three
years. For more information on the M.S. program, check our program page here or contact me directly.