1995 Eotvos Lorand University Budapest, Hungary Ph.D. Genetics and Molecular Biology
1987 Eotvos Lorand University Budapest, Hungary M.S. Genetics and Molecular Biology
Eva Sapi Ph.D. is a Professor and Department Chair at the Department of Biology and
Environmental Science where she teaches undergraduate and graduate biology courses
and carries out Lyme disease research with her graduate students.
Her research interest is to investigate the different forms of Borrelia burgdorferi
for the better understanding how Borrelia can hide from the immune system as well
as from antimicrobial therapies. Her recent research shows that Borrelia burgdorferi
is capable forming a protective layer around itself ? called biofilm ? which could
render it to be very resistant to antibiotics and provide a logical explanation as
to why extensive antibiotic treatment for patients with a tick-bite history could
fail. The goal of her research group is to fully characterize this novel form and
to identify novel antibacterial agents that are effective in killing all forms of
Dr. Sapi organized and chaired six Lyme Disease Symposiums at the University of New
Haven during the last several years.
Find out more about Dr. Sapi and connect with her online:
Lyme Disease, Pathogenic Biofilm, Antibiotics Resistance, Different Morphology of
Sapi E, Balasubramanian K, Poruri A, Maghsoudlou JS, Theophilus, PAS, Socarras KM,
Timmaraju AV, Filush KR, Gupta K, Shaikh, S, Luecke DF, MacDonald A, Zelger B. (2016)
Evidence of in vivo existence of borrelia biofilm in borrelial lymphocytomas European
Journal of Microbiology and Immunology, DOI:http://dx.doi.org/10.1556/1886.2015.00049
Sapi E, Theophilus, PAS, Burugu D, Luecke DF. (2016) Effect of Rpon, Rpos and Luxs
pathways on the biofilm formation and antibiotic sensitivity of Borrelia burgdorferi.
European Journal of Microbiology and Immunology, Dec 1; 6(4): 272–286.
Shaikh S, Timmaraju VA, Torres JP, Socarras KM, PAS, Sapi E. (2016) Influence of tick
and mammalian physiological temperatures on Borrelia burgdorferi biofilms. Microbiology,
Nov;162(11):1984-1995. doi: 10.1099/mic.0.000380.
Theophilus, PAS, Victoria MJ, Socarras KM, Filush KR, Gupta K, Luecke DF, Sapi E.
(2015) Effectiveness of Stevia rebaudiana whole leaf extract against the various morphological
forms of Borrelia burgdorferi in vitro European Journal of Microbiology and Immunology,
Timmaraju A, Theophilus PAS, Balasubramanian K, Luecke DF and Sapi E. Biofilm formation
by European Borrelia burgdorferi sensu lato strains in vitro. (2015) FEMS Letters,
doi: 10.1093/femsle/fnv120. Epub 2015 Jul 24.
Sapi E, Pabbati N, Datar D, Davies EM, Rattalle A, Kuo BA. (2013) Culture conditions
for the growth and detection of Borrelia from human serum. International Journal of
Medical Sciences 10(4):362-376. doi:10.7150/ijms.5698.
Sapi E, Bastian SL, Mpoy CM, Scott S, Rattelle A, Pabbati N, Poruri A, Burugu D, Theophilus
PAS, Pham TV, Datar D, Dhaliwal NK, Timmaraju A Rossi MJ, Sinha SK, MacDonald A and
Luecke DF. (2012) Characterization of biofilm formation by Borrelia burgdorferi in
vitro. PLoS ONE October 7(10): e48277.