Eva Sapi, Ph.D.

Eva Sapi Headshot
Professor
Chair of Biology

Biology and Environmental Science
College of Arts & Sciences
Education

1995 Eotvos Lorand University 
Budapest, Hungary 
Ph.D. Genetics and Molecular Biology 

1987 Eotvos Lorand University 
Budapest, Hungary 
M.S. Genetics and Molecular Biology 

About Eva

Eva Sapi Ph.D. is a Professor and Department Chair at the Department of Biology and Environmental Science where she teaches undergraduate and graduate biology courses and carries out Lyme disease research with her graduate students.

Her research interest is to investigate the different forms of Borrelia burgdorferi for the better understanding how Borrelia can hide from the immune system as well as from antimicrobial therapies. Her recent research shows that Borrelia burgdorferi is capable forming a protective layer around itself ? called biofilm ? which could render it to be very resistant to antibiotics and provide a logical explanation as to why extensive antibiotic treatment for patients with a tick-bite history could fail. The goal of her research group is to fully characterize this novel form and to identify novel antibacterial agents that are effective in killing all forms of Borrelia burgdorferi. 

Dr. Sapi organized and chaired six Lyme Disease Symposiums at the University of New Haven during the last several years. 

Find out more about Dr. Sapi and connect with her online: 

Lyme Disease Research Group  

https://www.facebook.com/UNH.LymeGroup  

Fields of Research

Lyme Disease, Pathogenic Biofilm, Antibiotics Resistance, Different Morphology of Borrelia burgdorferi

Recent Articles

Sapi E, Balasubramanian K, Poruri A, Maghsoudlou JS, Theophilus, PAS, Socarras KM, Timmaraju AV, Filush KR, Gupta K, Shaikh, S, Luecke DF, MacDonald A, Zelger B. (2016) Evidence of in vivo existence of borrelia biofilm in borrelial lymphocytomas European Journal of Microbiology and Immunology, DOI:http://dx.doi.org/10.1556/1886.2015.00049

Sapi E, Theophilus, PAS, Burugu D, Luecke DF. (2016) Effect of Rpon, Rpos and Luxs pathways on the biofilm formation and antibiotic sensitivity of Borrelia burgdorferi. European Journal of Microbiology and Immunology, Dec 1; 6(4): 272–286.

Shaikh S, Timmaraju VA, Torres JP, Socarras KM, PAS, Sapi E. (2016) Influence of tick and mammalian physiological temperatures on Borrelia burgdorferi biofilms. Microbiology, Nov;162(11):1984-1995. doi: 10.1099/mic.0.000380.

Theophilus, PAS, Victoria MJ, Socarras KM, Filush KR, Gupta K, Luecke DF, Sapi E. (2015) Effectiveness of Stevia rebaudiana whole leaf extract against the various morphological forms of Borrelia burgdorferi in vitro European Journal of Microbiology and Immunology, doi: 10.1556/1886.2015.00031

Timmaraju A, Theophilus PAS, Balasubramanian K, Luecke DF and Sapi E. Biofilm formation by European Borrelia burgdorferi sensu lato strains in vitro. (2015) FEMS Letters, doi: 10.1093/femsle/fnv120. Epub 2015 Jul 24.

Sapi E, Pabbati N, Datar D, Davies EM, Rattalle A, Kuo BA. (2013) Culture conditions for the growth and detection of Borrelia from human serum. International Journal of Medical Sciences 10(4):362-376. doi:10.7150/ijms.5698.

Sapi E, Bastian SL, Mpoy CM, Scott S, Rattelle A, Pabbati N, Poruri A, Burugu D, Theophilus PAS, Pham TV, Datar D, Dhaliwal NK, Timmaraju A Rossi MJ, Sinha SK, MacDonald A and Luecke DF. (2012) Characterization of biofilm formation by Borrelia burgdorferi in vitro. PLoS ONE October 7(10): e48277.

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In the Media

New Haven Register: University of New Haven Professor Studying Whether Stevia Can Kill Lyme Disease Bacteria

WEST HAVEN >> Could a common sweetener that's already in the kitchen cupboards in many American homes - stevia - prove to be an effective treatment for a disease as nasty and persistent as Lyme disease? Maybe even as good as or better than antibiotics? It's too early to say that for sure. But research by a University of New Haven biology professor and her students in the university's Lyme Disease Research Group, which still must be borne out by clinical trials, looks promising.