Severina N. Haddad, Ph.D.
Post-doctoral training, Yale Medical School
Ph.D., Dartmouth Medical School
B.S., University of New Hampshire
My research focuses on cellular and molecular biology of reproductive immunology. The overarching theme of my research is the communication between different cell types, as well as the interaction of the immune and endocrine systems. During my doctoral work, I examined estradiol regulation of uterine stromal fibroblast-secreted keratinocyte growth factor (KGF) on the innate immune function of uterine epithelial cells. As a post-doctoral associate, I examined embryo implantation into the endometrium and the effect of trophoblast cells on the maternal immune system. In addition, I studied how ovarian cancer cells “educate” the host immune system (i.e., macrophages) to be tolerant and even support tumor growth.
SN Haddad and CR Wira. Estradiol Regulation of Constitutive and Keratinocyte Growth Factor-induced CCL20 and CXCL1 Secretion by Mouse Uterine Epithelial Cells. American Journal of Reproductive Immunology, 72(1) 34 (2014).
JC Holmberg, S Haddad, V Wunsche, Y Yang, PB Aldo, Y Gnainsky, I Granot, N Dekel, and G Mor. An In Vitro Model for the Study of Human Implantation. American Journal of Reproductive Immunology, 67(2) 169 (2012).
SN Haddad and CR Wira. The Effect of Keratinocyte Growth Factor on Mouse Uterine Epithelial Cell Secretion of MIP3a and KC. American Journal of Reproductive Immunology, 64(3) 197 (2010).
DO Ochiel, JV Fahey, M Ghosh, SN Haddad and CR Wira. Innate Immunity in the Female Reproductive Tract: Role of Sex Hormones in Regulating Uterine Epithelial Cell Protection Against Pathogens. Current Women’s Health Reviews, 4(2) 102 (2008).
CR Wira, RM Rossoll, DO Ochiel, SN Haddad and TM Schaefer. Effect of Estradiol and PAMPS on Class II Mediated Antigen Presentation and Immunomodulatory Molecule Expression in the Mouse Female Reproductive Tract. American Journal of Reproductive Immunology, 55(6) 412 (2006).