Melanie Eldridge, Ph.D.

Research Interests

I am interested in using modern molecular tools to help find solutions to today's ecological challenges. Currently I study environmental contamination with chemicals that mimic human hormones using bioluminescent bioreporters that I have genetically engineered. The environment is increasingly contaminated with harmful chemicals, which may be having an effect on humans today and will certainly have an effect on the next few generations. I am also interested in the ecotoxicological effects of nanoparticles and metal-nanoparticle complexes. I enjoy working on projects that bridge the gap between ecosystem health and human health but also love projects that study different aspects of the two fields individually.

Recent Publications

M.L. Eldridge, F.-M. Menn, J. Sanseverino, G. Sayler (2013) Not all plastics have detectable estrogenic or androgenic activity. Food and Chemical Toxicology – In preparation. 

M.L. Eldridge, D.D. Fran?a, C.C. Montagner, G.A. Quináglia, G. Sayler, W.F. Jardim, G.A. Umbuzeiro (2013) Comparison of two yeast bioluminescent assays applied to water monitoring of estrogenic activity. Applied Research in Toxicology – In press. 

C. Krifaton, B. Kriszt, A. Risa, S. Szoboszlay, P. Harkai, M. Cserháti, M. Eldridge, J. Wang, J. Kukolya (2013) Application of a yeast estrogen reporter system for screening zearalenone degrading microbes. J Hazardous Materials 15:244-245. 

G.F. McCracken, J. Westbrook, V.A. Brown, M. Eldridge, P. Federico, T. Kunz (2012) Opportunistic predation by bats tracks and exploits changes in insect pest populations: evidence from quantitative (qPCR) analysis of fecal DNA. PLoS ONE 7:1-10. 

T.G. Osimitz, M.L. Eldridge, E. Sloter, W.J. Welsh, N. Ai, G.S. Sayler, F. Menn, C. Toole (2012) Lack of androgenicity and estrogenicity of the three monomers used in Eastman’s novel polyester plastic Tritan™. Food and Chemical Toxicology 50:2196-2205. 

W.F. Jardim, C.C. Montagner, I.C. Pescara, G.A. Umbuzeiro, A.M.D. Bergamasco, M.L. Eldridge, F. Fabriz Sodré (2012) An integrated approach to evaluate emerging contaminants in drinking water. Sep Purif Technol 84:3-8. 

A.M.D. Bergamasco, M. Eldridge, J. Sanseverino, F.F. Sodré, C.C. Montagner, I.C. Pescara, W.F. Jardim, G.A. Umbuzeiro (2011) Bioluminescent yeast estrogen assay (BLYES) as a sensitive tool to monitor surface and drinking water for estrogenicity. J Environ Monit 13:3288-3293. 

M.L. Eldridge, J. Sanseverino, G.A. Umbuzeiro, G. Sayler (2011) Analysis of environmental samples with yeast-based bioluminescent bioreporters. In E.O. Ekuayo (Ed.), Environmental Monitoring. Intech Publishers, Rijeka, Crotia. 

S. Ripp, M.L. DiClaudio (Eldridge), G.S. Sayler (2010) Biosensors as environmental monitors, p. 213-233. In R. Mitchell and J.D. Gu (Ed.), Environmental Microbiology, 2nd Ed. Wiley-Blackwell, Hoboken, New Jersey. 

J. Sanseverino, M.L. Eldridge, A.C. Layton, J.P. Easter, J. Yarbrough, T.W. Schultz, G.S. Sayler (2009) Screening of potentially hormonally active chemicals using bioluminescent yeast bioreporters. Toxicol Sci 107:122-134. 

K. Hill, P. Dutta, A. Zareba, M.L. Eldridge, M. Sepaniak (2008) Morphological and chemical optimization of microcantilever surfaces for thyroid system biosensing and beyond. Analytica Chimca Acta 625:55-62. 

M.L. Eldridge, J. Sanseverino, A.C. Layton, G.S. Sayler (2007) Saccharomyces cerevisiae (BLYAS): a new bioluminescent bioreporter for the detection of androgenic compounds. Appl Environ Microbiol 73:6012-6018. 

M.L. Eldridge, M.W. Cadotte, A.E. Rozmus, S.W. Wilhelm (2007) The response of bacterial functional groups to changes in available iron in the Eastern subtropical Pacific Ocean. J Experim Mar Biol Ecol 348:11-22. 

S.W. Wilhelm, M.J. Carberry, M.L. Eldridge, L. Poorvin, M.A. Saxton, M.A. Dobson (2006) Marine and freshwater cyanophages in a laurentian Great Lake: evidence from infectivity assay and molecular analyses of g20 genes. Appl Environ Microbiol 72:4957-49632. 

S.W. Wilhelm, G.S. Bullerjahn, M.L. Eldridge, J.M. Rinto-Kanto, L. Poorvin, R.A. Bourbonniere (2006) Seasonal hypoxia and the genetic diversity of prokaryote populations in the central basin hypolimnion of Lake Erie: evidence for abundant cyanobacteria and photosynthesis. J Great Lakes Res 32:657-671. 

M.L. Eldridge, C.G. Trick, M. Alm, G.R. DiTullio, E.L. Rue, K.W. Bruland, D.A. Hutchins, S.W. Wilhelm (2004) The response of the marine phytoplankton community to a manipulation of bioavailable iron in HNLC waters of the subtropical Pacific Ocean. Aquat Microb Ecol 35:79-91. 

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