Ph.D. in Medicinal Chemistry, University of Michigan, 1975
M.S. in Medicinal Chemistry, University of Michigan, 1971
B.S. in Chemistry, Drexel University, 1970. (Magna cum laude) Papers
Saggiomo, A.J., Asai, M. and Schwartz, P.M. Alcoholation of the trifluoromethyl
group. I. Ortho esters derived from 1- and 3-trifluoromethyl phenothiazines. J. Het. Chem.,
6:631, 1969.
Schwartz, P.M. and Saggiomo, A.J. Alcoholation of the trifluoromethyl group. II. A
facile synthesis of 6,12- dimethoxydibenzo (b,f) (1,5)diazocine from o-amino- benzotrifluoride. J.
Het. Chem., 9:947, 1972.
Schwartz, P.M., Shipman, C., Jr., Carlson, R.H. and Drach, J.C. Thermal inactivation as
a means of inhibiting the serum-associated deamination of 9-β-D-arabinofuranosyladenine in
tissue culture media. Antimicrob. Ag. Chemother., 5:337, 1974.
Schwartz, P.M. and Drach, J.C. Separation of arabinosyl, ribosyl and deoxyribosyl
purine nucleotides by thin-layer chromatography. J. Chromatog., 106:20, 1975.
Schwartz, P.M., Shipman, C., Jr. and Drach, J.C. Antiviral activity of arabinosyladenine
and arabinosylhypoxanthine in herpes simplex virus- infected KB cells. II. Selective inhibition of
viral DNA synthesis in the presence of an adenosine deaminase inhibitor. Antimicrob. Ag.
Chemother., 10:64, 1976.
Schwartz, P.M. and Drach, J.C. Thin-layer chromatography of purine bases, nucleosides
and nucleotides. In: Nucleic Acid Chemistry: Improved and New Synthetic Procedures,
Methods and Techniques. L.B. Townsend and R.S. Tipson, eds., Wiley and Sons, Part 2, pp
1061, 1978.
Schwartz, P.M. and Handschumacher, R.E. Selective antagonism of 5-fluorouracil
cytotoxicity by allopurinol in vitro. Cancer Res., 39:3095, 1979.
Handschumacher, R.E., Schwartz, P.M. and Moyer, J.D. Some consequences of
inhibition of the de novo pathway of pyrimidine biosynthesis. In: Antimetabolites in
Biochemistry, Biology and Medicine. J. Skoda and P. Langen, eds., Pergamon Press, pp 297,
1979.
Schwartz, P.M., Dunigan, J.M., Marsh, J.C. and Handschumacher, R.E. Allopurinol
modification of the toxicity and anti-tumor activity of 5-fluorouracil. Cancer Res., 40:1885, 1980.
Kerkering, T.M., Schwartz, P.M., Espinel-Ingeroff, A., Turek, P.J. and Diasio, R.B. 5-
Fluorocytosine sensitivity of pathogenic fungi in the presence of allopurinol: Potential for
improving the therapeutic index of 5-fluorocytosine. Antimicrob. Ag. Chemother., 24: 488, 1983.
Schwartz, P.M., Novack, J.N., Shipman C., Jr. and Drach, J.C. Metabolism of
arabinosyladenine in herpes simplex virus-infected and uninfected cells: Correlation with
inhibition of DNA synthesis and role in anti-viral selectivity. Biochem. Pharmacol., 33:2431,
1984.
Schwartz, P.M., Turek, P.J., Hyde, C.M., Cadman, E.C. and Handschumacher, R.E.
Altered plasma kinetics of 5-fluoro-uracil at high dosage in rat and man. Cancer Treat. Rept.,
69:133, 1985.
Schwartz, P.M., Moir, R.D., Hyde, C.M., Turek, P.J. and Handschumacher, R.E.,
Role of uridine phosphorylase in the anabolism of 5-fluorouracil. Biochem. Pharmacol., 34:3585,
1985.
Schwartz, P.M., Kugelman, L.C., Coifman, Y., Hough, L.M. and Milstone, L.M. Human
keratinocytes catabolize thymidine. J. Invest. Dermatol., 90:8, 1988.
Schwartz, P.M. and Milstone, L.M. Thymidine phosphorylase in human epidermal
keratinocytes. Biochem. Pharmacol., 37:353, 1988.
Schwartz, P.M., Reuveni, H. and Milstone, L.M. Local and systemic implications of
thymidine catabolism by the human epidermis. Proc. NYAS, 548:115, 1988.
Schwartz, P.M. and Milstone, L.M. Dipyridamole potentiates the growth-inhibiting
activity of methotrexate and 5-fluorouracil in human keratinocytes in vitro. J. Invest. Dermatol.,
93:523, 1989.
Reuveni, H., Bull, C.O., Landry, M.L., Milstone, L.M. and Schwartz, P.M. Antiviral
activity of 5-iodo-2'-deoxyuridine and related drugs in human keratinocytes infected in vitro with
herpes simplex virus, type 1. Skin Pharmacol. 4: 291, 1991.
Schwartz, P.M., Barnett, S.K. and Reuveni, H. Thymidine salvage changes with
differentiation in human keratinocytes in vitro. J. Invest. Dermatol., 97: 1057, 1991.
Schwartz, P.M., Barnett, S.K., Atillasoy, E.J. and Milstone, L.M. Methotrexate induces
differentiation of human keratinocytes. Proc. Natl. Acad. Sci., USA, 89:594, 1992.
Schwartz, P.M., Barnett, S.K. and Milstone, L.M. Keratinocytes differentiate in response
to inhibitors of deoxyribonucleotide synthesis. J. Dermatologic Sci. 9: 129, 1995.
Fenjves, E.S., Schwartz, P.M. Blaese, R.M., and Taichman, L.B. Keratinocyte gene
therapy for adenosine deaminase deficiency: A model approach for inherited metabolic disorders. Gene Therapy, 8: 911-917, 1997.
Human
Schwartz, P.M., Haggerty, J.G. and Cheng, Y-C. β-L-1,3-Dioxolane-cytidine: A novel
nucleoside that inhibits proliferation and induces differentiation of keratinocytes in vitro. Skin
Pharmacol, 11: 207-213, 1998.
Asgari, M.M., Haggerty, J.G., McNiff, J.M., Milstone, L.M. and Schwartz, P.M.
Expression and localization of thymidine phosphorylase/platelet-derived endothelial cell growth
factor in skin and epidermal tumors. J Cut. Pathol. 26: 287-294, 1999.
Milstone, L.M., Asgari, M.M., Schwartz, P.M. and Hardin-Young, J. Growth factor
expression, healing and structural characteristics of Grafskin (Apligraf®). Wounds, 12: 12-19,
2000.
Milstone, L.M. and Schwartz, P.M. Engineering better skin. In: Skin, The Barrier Zone,
S. Klaus and J. Hamburger, eds. (in press).
Menon, G.K., Brandsma, J.L. and Schwartz, P.M. Gene gun and the human skin:
Ultrastructural observations on particle distribution and barrier structures. (in preparation)
Haggerty, J.G., Sheu, S.M., Gettler, S. and Schwartz, P.M. Function and localization of
thymidine phosphorylase in human skin. (in preparation).
Haggerty, J.G., Menon, G.K. and Schwartz, P.M. Intracellular biosynthesis of ascorbic
acid by human keratinocytes and fibroblasts: Introduction of gulonolactone oxidase. (in
preparation). Undergraduate:
CH501 Advanced Organic Chemistry
CH412 Seminar
CH351 * Qualitative Organic Chemistry
CH341 Synthetic Methods in Chemistry
CH201-CH204 Organic Chemistry I and II and Laboratories
CH115-CH118 General Chemistry I and II and Laboratories
CH107, CH108 * Introduction to Organic Chemistry and Laboratory
CH105 Introduction to General and Organic Chemistry with Laboratory
CH103 , CH104 Introduction to General Chemistry and Laboratory
EAS 120 General Chemistry with Applications to Biosystems
* no longer offered
Graduate:
CH650 Medicinal Chemistry
CH655 Pharmacology Doctoral Dissertation
9-β-D-Arabinofuranosyladenine: Metabolism and Effects of Virus Replication and DNA
Synthesis in Uninfected and Herpes Simplex Virus-Infected KB Cells. Doctorate in Medicinal
Chemistry. The University of Michigan, 1975 University Committees and Professional Service
Coordinator Graduate Program in Medicinal Chemistry
Academic Computing Committee (member)
Student Retention Committee (member)
Institutional Review Board (member)
SEAS Dean Search Committee (member) Recent Professional Development Activities and Grants
Visiting Associate Professor – Yale University School of Medicine
UNH-Bayer Alliance Equipment Grant (2004) – “The Interactive ChemistryClassroom”
Council of Graduate Schools/ Sloan Foundation Planning Grant (2004) – Master’s Degree Program in Medicinal Chemistry
Dreyfus Foundation Special Grant in the Chemical Sciences (2005 – submitted) –“Exploring the World of Medicinal Chemistry: Design, Synthesis and Testing ofAntibacterial Agents”
UNH Summer Fellowship – “New Approaches for Chemotherapy of Papilloma Virus Infections” (2005) Patents (held by Yale University)
Milstone, L.M. and Schwartz, P.M. Compositions and Methods for Treating Cutaneous
Hyperproliferative Disorders. Issued September 7, 1993. Patent Number: 5,242,921.
Milstone, L.M. and Schwartz, P.M. Method for the Treatment of Hyperproliferative Disorders.
Issued July 5, 1994. Patent Number: 5,326,764.
Schwartz, P.M. Epidermal Biosensors: Continuous, Early, Sensitive Monitors for Onset of
Specific Diseases. (Provisional Patent) |
