Pier Cirillo

Education

Ph.D. in Synthetic Organic Chemistry, Boston University, 1995
B.Sc. Hons. in Chemistry, University of the Witwatersrand, 1987

Selected Scholarly Publications

Cirillo, Pier F.; Hickey, Eugene; Breitfelder, Steffen; Betageri, Raj; Fadra, Tazmeen; Gaenzler, Faith; Gilmore, Thomas; Goldberg, Daniel; Kamhi, Victor; Kirrane, Thomas; Kroe, Rachel R.; Madwed, Jeffrey; Moriak, Monica; Netherton, Matthew; Pargellis, Christopher A.; Patel, Usha; Qian, Kevin C.; Regan, John R.; Sharma, Rajiv; Sun, Sanxing; Swinamer, Alan; Torcellini, Carol; Takahashi, Hidenori; Tsang, Michele, Xiong, Zhaoming; Moss, Neil  Discovery and Characterization of the N-Phenyl-N’-Naphthylurea Class of p38 MAP Kinase Inhibitors. Bioorganic and Medicinal Chemistry Letters (2009), 19(9), 2386-2391.

Regan, John; Capolino, Alison; Cirillo, Pier F.; Gilmore, Thomas; Graham, Anne G.; Hickey, Eugene; Kroe, Rachel R.; Madwed, Jeffrey; Moriak, Monica; Nelson, Richard; Pargellis, Christopher A.; Swinamer, Alan; Torcellini, Carol; Tsang, Michele; Moss, Neil.  Structure-Activity Relationships of the p38a MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea (BIRB 796).    Journal of Medicinal Chemistry (2003), 46(22), 4676-4686.

Cirillo, Pier F.; Pargellis, Christopher; Regan, John. The non-diaryl heterocycle classes of p38 MAP kinase inhibitors. Current Topics in Medicinal Chemistry (Hilversum, Netherlands) (2002), 2(9), 1021-1035.

Regan, John; Breitfelder, Steffen; Cirillo, Pier; Gilmore, Thomas; Graham, Anne G.; Hickey, Eugene; Klaus, Bernhard; Madwed, Jeffrey; Moriak, Monica; Moss, Neil; Pargellis, Chris; Pav, Sue; Proto, Alfred; Swinamer, Alan; Tong, Liang; Torcellini, Carol.  Pyrazole Urea-Based Inhibitors of p38 MAP Kinase: From Lead Compound to Clinical Candidate. Journal of Medicinal Chemistry (2002), 45(14), 2994-3008.

Pargellis, Christopher; Tong, Liang; Churchill, Laurie; Cirillo, Pier F.; Gilmore, Thomas; Graham, Anne G.; Grob, Peter M.; Hickey, Eugene R.; Moss, Neil; Pav, Susan; Regan, John.  Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nature Structural Biology (2002), 9(4), 268-272.

Cirillo, Pier F.; Danishefsky, Samuel J.  The glycal assembly method on solid supports: synthesis of oligosaccharides and glycoconjugates.  Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries (2001), 15-40. P.H. Seeberger Ed., Wiley, New York.

Danishefsky, Samuel J.; Hu, Shuanghua; Cirillo, Pier F.; Eckhardt, Matthias; Seeberger, Peter H.  A highly convergent total synthetic route to glycopeptides carrying a high-mannose core pentasaccharide domain N-linked to a natural peptide motif.   Chemistry-A European Journal (1997), 3(10), 1617-1628.

Seeberger, Peter H.; Cirillo, Pier F.; Hu, Shuanghua; Beebe, Xenia; Bilodeau, Mark T.; Danishefsky, Samuel J.  Synthesis of the pentasaccharide core structure of asparagine-linked glycoprotein oligosaccharides by the glycal assembly method. Enantiomer (1996), 1(4-6), 311-323.

Jain, Nareshkumar F.; Cirillo, Pier F.; Pelletier, Roberta; Panek, James S.  Double stereodifferentiation in the Lewis acid promoted crotylation of (S)-2-alkoxypropanal with chiral b-alkyl (E)-crotylsilanes. Tetrahedron Letters (1995), 36(48), 8727-30.

Cirillo, Pier F.; Panek, James S.  Studies directed toward the synthesis of (+)-sesbanimide A: construction of the AB-ring system (a formal total synthesis). Journal of Organic Chemistry (1994), 59(11), 3055-63.

Panek, James S.; Cirillo, Pier F.  Acyclic diastereoselectivity in the Lewis acid promoted additions of chiral, b-methyl-substituted (E)-crotylsilanes with achiral aldehydes. Journal of Organic Chemistry (1993), 58(5), 999-1002. Cirillo, Pier F.; Panek, James S.  Recent progress in the chemistry of acylsilanes.  A review. Organic Preparations and Procedures International (1992), 24(5), 553-82.

Cirillo, Pier F.; Panek, James S.  Diastereoselectivity in nucleophilic addition reactions to (a,b-dialkoxyacyl) silanes:  an operationally useful route to optically active 1,2,3-syn-triols.  Journal of Organic Chemistry (1990), 55(25), 6071-3.

Panek, James S.; Cirillo, Pier F. p-Facial selectivity in catalytic osmylation reactions of chiral C1-oxygenated allylic silanes.  Journal of the American Chemical Society (1990), 112(12), 4873-8.

Doctoral Dissertation

Chiral Allylic Silanes in Organic Synthesis: Formal Synthesis of (+)-Sesbanimide A.  Doctorate in Philosophy. Boston University, 1995

Issued US Patents

US 7,928,123 Compounds which modulate the CB2 receptor. Issued Apr 19, 2011
US 7,935,715 Compounds which modulate the CB2 receptor. Issued May 03, 2011
US 6,080,763 Aromatic heterocyclic compounds and their use as anti-inflammatory agents. Issued Jun 27, 2000
US 6,228,881 Aromatic heterocyclic compounds and their use as anti-inflammatory agents. Issued May 08, 2001
US 6,319,921 Aromatic heterocyclic compound as antiinflammatory agents. Issued Nov 20, 2001 
US 6,242,453 Polycyclo heterocyclic derivatives as antiinflammatory agents. Issued Jun 05, 2001 
US 6,297,381 Aromatic heterocyclic compounds as anti-inflammatory agents. Issued Oct 02, 2001
US 6,358,945 Compounds useful as anti-inflammatory agents. Issued Mar 19, 2002 
US 6,492,393 Compounds useful as anti-inflammatory agents.  Issued Dec 10, 2002 
US 6,476,023 Aromatic heterocyclic compounds as anti-inflammatory agents. Issued Nov 05, 2002
US 6,608,052 Compounds useful as anti-inflammatory agents Issued Aug 19, 2003
US 6,333,325 Method of treating cytokine mediated diseases or conditions. Issued Dec 25, 2001 
US 6,329,415 Aromatic heterocyclic compounds as antiinflammatory agents. Issued Dec 11, 2001 
US 6,660,732 Compounds useful as anti-inflammatory agents. Issued Dec 09, 2003
US 7,026,476 Intermediate arylamine compounds. Issued Apr 11, 2006 
US 7,019,006 Compounds useful as anti-inflammatory agents. Issued Mar 28, 2006.

Courses Taught

CH501 Advanced Organic Chemistry 
CH201 Organic Chemistry I and Laboratories
CH115  General Chemistry I and Laboratories
CH105 Laboratory

Recent Professional Acitivities

Medicinal Chemistry Consultant – L2 Diagnostics, since 2011

Principal Scientist – Boehringer Ingelheim Pharmaceuticals, Inc.  2003-2008

Senior Scientist – Boehringer Ingelheim Pharmaceuticals, Inc.  1997-2002

Post-Doctoral Research Fellow – Memorial Sloan-Kettering Cancer Center  1995-1996